Jaundice is likely to be a sign of:

Jaundice is characterized by a yellowing of the skin and eyes, resulting from elevated levels of bilirubin in the blood. This condition often indicates liver dysfunction or hemolysis, where red blood cells are broken down more rapidly than usual.

In this context, sickle cell anemia is associated with jaundice due to the high rate of hemolysis that occurs in this condition. Individuals with sickle cell anemia have abnormal hemoglobin that can lead to the destruction of red blood cells at a significantly increased rate. As these cells rupture, hemoglobin is released into the bloodstream, which is then converted into bilirubin. When the liver is unable to process this excess bilirubin effectively, the result is jaundice.

Other options presented are conditions that may not typically manifest with jaundice. Acute leukemia, while it can involve the liver, does not primarily cause jaundice as a standard symptom. Aplastic anemia does not lead to increased hemolysis, and iron-deficiency anemia is primarily about a lack of iron and does not typically involve hemolysis either, making jaundice unlikely in these cases. Thus, sickle cell anemia is the most fitting condition that is likely to present with jaundice due to its characteristic hemolytic properties.