Which of the following is NOT a systemic manifestation of inflammation?

In the context of inflammation, systemic manifestations refer to the body's overall response that can be felt throughout the system, rather than being localized to a specific area.

Fatigue, malaise, and pyrexia (fever) are all common systemic manifestations of inflammation. Fatigue often occurs as the body redirects its energy to fighting inflammation, malaise is a general feeling of discomfort or unease that frequently accompanies illness, and pyrexia is the body's systemic response to infection or injury, raising the temperature as part of the defense mechanism.

On the other hand, redness of the inflamed area is a localized manifestation. It specifically pertains to the area of inflammation and results from increased blood flow due to vasodilation and the accumulation of inflammatory mediators at the site of injury or infection. This localized response contrasts with the systemic nature of the other manifestations listed, which are felt throughout the body rather than in one specific region. Thus, identifying redness as not being a systemic manifestation of inflammation underlines its nature as a localized response to tissue injury.