Which of the following is a clinical feature of systemic lupus erythematosus?

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by widespread inflammation that affects multiple organ systems in the body. One of the hallmark features of this condition is the involvement of various organs, which can include the skin, joints, kidneys, heart, lungs, and nervous system. This multifaceted involvement is indicative of the systemic nature of the disease.

The clinical manifestations of SLE can vary widely among individuals, but organ inflammation is a common aspect, leading to symptoms such as joint pain, skin rashes, and renal issues. This extensive impact on multiple organs distinguishes SLE from other conditions that may have more localized symptoms.

In contrast, acute onset and nonprogressive courses are not typical for SLE, which is known for its relapsing-remitting nature and can have varied progression. The lack of a specific diagnostic blood test doesn't align with SLE either, as there are several laboratory tests, such as the antinuclear antibody (ANA) test, that are used in its diagnosis. While skin rashes can occur in SLE, they are not specific to the chest and back, and various rash patterns may be seen across different parts of the body.

Thus, the correct choice highlights the essential characteristic of